Selection of research articles and reviews. Click here for a complete list on Pubmed

Research Articles

Zheng Y, Lewis TL Jr, Igo P, Polleux F, Chatterjee A. (2016) Virus-Enabled Optimization and Delivery of the Genetic Machinery for Efficient Unnatural Amino Acid Mutagenesis in Mammalian Cells and Tissues. ACS Synth Biol. 2016 Aug 9. Link

Kwon SK, Sando R 3rd, Lewis TL, Hirabayashi Y, Maximov A, Polleux F. (2016) LKB1 Regulates Mitochondria-Dependent Presynaptic Calcium Clearance and Neurotransmitter Release Properties at Excitatory Synapses along Cortical Axons. PLoS Biology, 2016 Jul; 14(7): e1002516. Link

Fossati M, Pizzarelli R, Schmidt ER, Kupferman JV, Stroebel D, Polleux F*, Charrier C.* (2016) SRGAP2 and Its Human-Specific Paralog Co-Regulate the Development of Excitatory and Inhibitory Synapses. Neuron. 2016 Jul 20;91(2):356-69. Link

*Co-corresponding authors

See Preview by Subramanian and Nedivi in the same Issue Link


Shimojo M, Courchet J, Pieraut S, Torabi-Rander N, Sando R 3rd, Polleux F, Maximov A. (2015)  SNAREs Controlling Vesicular Release of BDNF and Development of Callosal Axons. Cell Reports 11(7):1054-66. Link

Hsia HE, Takeda M, Courchet J, Goebbels S, An W, Eickholt B, Polleux F, Rotin D, Wu H, Nave KA, Rossner M, Brose N, Kawabe H. (2014) The Ubiquitin E3 Ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite outgrowth. PNAS 111(36):13205-10. Link

Courchet J.*, Lewis T. Jr*, Aizawa S. and Polleux F. (2013) Terminal axon branching is regulated by the LKB1-NUAK1 kinase pathway via presynaptic mitochondrial capture.
Cell 153:1510-1525. Link

*Contributed equally to this work.

Mairet-Coello G, Courchet J, Pieraut S, Courchet V, Maximov A and Polleux F. (2013)
The CAMKK2-AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Abeta Oligomers through Tau Phosphorylation.
Neuron 78:94-108. Link

Charrier C*, Joshi K*, Coutinho-Budd J, Kim JE, Lambert N, de Marchena J, Jin WL, Vanderhaeghen P, Ghosh A, Sassa T, Polleux F. (2012)
Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation.
Cell 149:923-35. Epub 2012 May 3. Link here.

* Contributed equally to this work.

Coutinho-Budd J, Ghukasyan V, Zylka MJ, Polleux F. (2012)
The F-BAR domains from SRGAP1, SRGAP2 and SRGAP3 differentially regulate membrane deformation.
Journal of Cell Science 125:3390-401. Epub 2012 Mar 30. Link

Hand R., Polleux F. (2011)
Neurogenin2 regulates the initial axon guidance of cortical pyramidal neurons projecting medially to the corpus callosum.
Neural Development Aug 24; 6:30. Link

Williams T*., Courchet J.*, Viollet B., Brenman J.E., Polleux F. (2011)
AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress.
Proc Natl Acad Sci U S A. 108:5849-54. Link

* Contributed equally to this work.

Yi J.J., Barnes A.P., Hand R., Polleux F. and Ehlers M.D. (2010)
TGFβ signaling specifies axons during brain development.
Cell 142:144-57. Link

Guerrier S., Coutinho-Budd J., Sassa T., Vincent-Jordan N., Frost A., and Polleux F. (2009)
The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis.
Cell 138:990-1004. Link

Bortone D. and Polleux F. (2009)
KCC2 expression promotes the termination of cortical interneuron migration in a voltage-sensitive calcium-dependent manner.
Neuron 62:53-71. (Featured Article). Link

Powell A., Sassa T., Wu Y.Q., Tessier-Lavigne M., and Polleux F. (2008)
Netrin-1 specifies the topography of thalamocortical projections in the ventral telencephalon through its attractive and repulsive activities.
PLoS Biology 6(5):e116. Link

Barnes A.P., Lilley B., Pan, A. Plummer L, Powell A., Raines, A, Sanes J.R., Polleux F. (2007)
LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons.
Cell 129 :549-563. Link

Hand R*, Bortone D*, Mattar P, N’Guyen L, Heng JI-T, Guerrier S, Boutt E, Peters E, Barnes, AP, Parras C, Schuurmans C, Guillemot F and Polleux F. (2005)
Phosphorylation of Neurogenin2 specifies the migration properties and the dendritic morphology of pyramidal neurons in the neocortex.
Neuron 48:45-62. Link

* Contributed equally to this work.

Seibt J., Schuurmans C., Gradwhol G., Dehay C., Vanderhaeghen P., Guillemot, F. and Polleux F. (2003)
Neurogenin2 specifies the connectivity of thalamic neurons by controlling axon responsiveness to intermediate target cues.
Neuron 39:439-452. Link 

Dufour A., Seibt J., Passante L., Depaepe V., Ciossek T., Frisén J., Kullander J., Flanagan J.G., Polleux F. and Vanderhaeghen P. (2003)
Area-Specificity and topography of thalamocortical projections controlled by ephrin/Eph genes. Neuron 39:453-465. Link

Review Articles

Kwon SK, Hirabayashi Y, and Polleux F. (2016). Organelle-Specific Sensors for Monitoring Ca2+ Dynamics in Neurons. Frontiers in Synaptic Neuroscience, 16 September 2016. Link

Mairet-Coello G. and Polleux F. (2014) Involvement of ‘stress-response’ kinase pathways in Alzheimer’s disease progression. Current Opinion in Neurobiology 27:110-117.

Lewis T.L. Jr, Courchet J. and Polleux F. (2013) Cell biology of Neuroscience: Cellular and Molecular mechanisms underlying axon formation, growth and branching.

The Journal of Cell Biology 202:837-48.

Barnes A.P., and Polleux F. (2009)
Establishment of Axon-Dendrite Polarity in Developing Neurons.
Annual Review of Neuroscience 32:347-81. Link

Barnes A.P., Solecki D. and Polleux F. (2008)
New insights into the molecular mechanisms specifying neuronal polarity in vivo.
Current Opinion in Neurobiology 18:44-52. Link

Polleux F., Ince-Dunn G., Ghosh A. (2007)
Transcriptional mechanisms specifying neuronal connectivity and synapse formation.
Nature Reviews Neuroscience 8:331-340. Link

Vanderhaeghen P. and Polleux F. (2004) Developmental mechanisms patterning thalamocortical projections: intrinsic, extrinsic and in between.
Trends in Neurosciences 25:127-149. Link

Whitford, K.L., Dijkhuizen P., Polleux F., and Ghosh A. (2002)
Molecular control of dendritic development.
Annual Review of Neuroscience 25:127-149. Link

Previous publications from Franck

Polleux F., Whitford K., Dijkhuizen P. and Ghosh A. (2002)
Control of cortical interneuron migration by neurotrophins and PI3-Kinase signaling.
Development 129:3147-3160. Link

Polleux F., Dehay C. and Kennedy H. (2001)
Pre- and post-mitotic events contribute to the progressive acquisition of area-specific connectional fate in the neocortex.
Cerebral Cortex 11:1027-1039. Link

Polleux F., Morrow T. and Ghosh A. (2000)
Semaphorin 3A is a chemoattractant for cortical apical dendrites.
Nature 404:567-573. (Full Article +Cover +News & Views). Link

Polleux F., Giger R.J., Ginty, D.D. Kolodkin A.L. and Ghosh A. (1998)
Patterning of cortical efferent projections by semaphorin-neuropilin interactions.
Science 282: 1904-1906. Link

Polleux F., Dehay C. and Kennedy H. (1998)
Neurogenesis and commitment of corticospinal neurons in the reeler mutant mouse.
J. Neurosci. 18: 9910-9923. Link

Polleux F., Dehay C., Moraillon B. and Kennedy H. (1997)
Regulation of neuroblast cell-cycle kinetics plays a crucial role in the generation of unique features of neocortical areas.
J. Neurosci. 17: 7763-7783. Link

Polleux F., Dehay C. and Kennedy H. (1997)
The timetable of laminar neurogenesis contributes to the specification of cortical areas in mouse isocortex.
J. Comp. Neurol. 385:95-116. Link